Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death

Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death

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Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis.In the present study, we report that pekinenin E (PE), a casbane diterpenoid derived from the roots of Euphorbia pekinensis, has a strong antitumor activity against human HCC cells both in vitro and in vivo.PE suppressed the growth of human HCC cells Hep G2 and SMMC-7721.In addition, PE-mediated endoplasmic reticulum (ER) stress caused canine spectra kc 3 intranasal single dose increasing expressions of C/EBP homologous protein (CHOP), leading to apoptosis in HCC cells both in vitro and in vivo.Inhibition of ER stress wella color charm 050 cooling violet with CHOP small interfering RNA or 4-phenyl-butyric acid partially reversed PE-induced cell death.

Furthermore, PE induced S cell cycle arrest, which could also be partially reversed by CHOP knockdown.In all, these findings suggest that PE causes ER stress-associated cell death and cell cycle arrest, and it may serve as a potent agent for curing human HCC.